Title of article
A PNA-DNA linker synthesis of N-((4,4′-dimethoxytrityloxy)ethyl)-N-(thymin-1-ylacetyl)glycine
Author/Authors
Kenneth H. Petersen، نويسنده , , Dorte K. Jensen، نويسنده , , Michael Egholm، نويسنده , , Peter E. Nielsen، نويسنده , , Ole Buchardt، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
1119
To page
1124
Abstract
N-(2-benzyloxyethyl)-N-(thymin-1-ylacetyl)glycine was synthesised and used as a linker for coupling DNA and PNA together. Three different 10-mers composed of 6 DNA units and 4 PNA thymine units were made. The PNA-DNA chimera hybridise to complementary DNA or PNA oligomers, and both the PNA and the DNA part of the chimera are involved in the binding.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787479
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