Title of article :
Active-site conformation of 17-(3-pyridyl)androsta-5,16-dien-3β-ol, a potent inhibitor of the P450 enzyme C17α-hydroxylase/C17-20 lyase
Author/Authors :
David F. Burke، نويسنده , , Charles A. Laughton، نويسنده , , Chris F. Snook، نويسنده , , Stephen Neidle، نويسنده , , Gerard A. Potter and، نويسنده , , Michael Jarman، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1995
Abstract :
17-(3-pyridyl)androsta-5,16-dien-3β-ol, a nanomolar inhibitor of the P450 enzyme C17α-hydroxylase/C17-20 lyase, is a target for prostate cancer chemotherapy. A model is presented for the inhibitor docked into the structure of the enzyme.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
