Synthesis of peptide nucleic acids (PNA) by submonomer solid-phase synthesis

A simple, versatile method for the synthesis of Peptide Nucleic Acids (PNA) from readily available building blocks has been developed. The approach is based on submonomer solid phase synthesis and allows for the structural variation of both the backbone and the nucleobase sidechain. The efficiency of the method was demonstrated by the synthesis of PNA oligomers in high purity and good yields.