Title of article
Photoactivatable analogues of a Substance P non-peptidic antagonist, for probing the antagonist binding site of the NK1 receptor
Author/Authors
Ian D. Kersey، نويسنده , , Colin W. G. Fishwick، نويسنده , , John B. C. Findlay، نويسنده , , Peter Ward-Booth، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
4
From page
1271
To page
1274
Abstract
(+)-(2S,3S)-3-(2-methoxybenzylamino)-2-phenylpiperidine (CP-99,994) binds with high affinity (pKi 9.6) to the human NK1 receptor. Racemic analogues of CP-99,994 containing either benzoyl or diazirinyl moieties also bind with high affinity (pKi 9.4 and 9.1 respectively). These analogues are of tremendous potential for mapping the antagonist binding site of the NK1 receptor.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787509
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