Author/Authors :
Patrick J. Casara، نويسنده , , Jean-Michel Altenburger، نويسنده , , Debra L. Taylor، نويسنده , , A. Stanley Tyms، نويسنده , , Michael Kenny، نويسنده , , Jean-François Navé، نويسنده ,
Abstract :
The synthesis, anti-HIV-1 and anti-herpesvirus activities of new rigid acyclonucleotide analogs are described. 9-[2-methylidene-3-(phosphonomethoxy)propyl]guanine 1a exhibits in vitro anti-HIV-1 activity similar to that of the antiviral agent 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). Compound 1a is 9-fold less toxic to human T-lymphoid cells MT-4 than PMEA.
