Title of article
1,2,3-Trisubstituted cyclohexyl substance P antagonists: significance of the ring nitrogen in piperidine-based NK-1 receptor antagonists
Author/Authors
Sander G. Mills، نويسنده , , Malcolm MacCoss، نويسنده , , Dennis Underwood، نويسنده , , Shrenik K. Shah، نويسنده , , Paul E. Finke، نويسنده , , Timothy F. Miller and Daniel J. Miller، نويسنده , , Richard J. Budhu، نويسنده , , Margaret A. Cascieri، نويسنده , , Sharon Sadowski، نويسنده , , Catherine D. Strader، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
1345
To page
1350
Abstract
A stereocontrolled synthesis of 1-benzyloxy-2-phenylcyclohexane derivatives containing polar substituents at C3 is described. These compounds, designed to test the role of the ring nitrogen in a related series of potent piperidine-based substance P antagonists, show similar NK-1 receptor affinity, indicating that the nitrogen may serve a largely structural role in N-substituted piperidine antagonists.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787522
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