Title of article
LTD4 Receptor binding activity of novel pyridine chromanols: qualitative correlation with pKa
Author/Authors
Hiroko Masamune، نويسنده , , James F. Eggler، نويسنده , , Anthony Marfat، نويسنده , , Lawrence S. Melvin Jr.، نويسنده , , Frank W. Rusek، نويسنده , , Jeanene E. Tickner، نويسنده , , John B. Cheng، نويسنده , , John T. Shirley، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
1371
To page
1376
Abstract
A series of pyridine chromanols were synthesized and evaluated as LTD4-antagonists (LTD4-A). The quinoline sidechain of this class of such agents, as exemplified by REV-5901, has until now been deemed as essential for potent activity. However, by manipulating substituents on a pyridine ring, quinoline-like potency can be achieved. The results indicate that this is a function of pKa.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787526
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