Author/Authors :
Hiroko Masamune، نويسنده , , James F. Eggler، نويسنده , , Anthony Marfat، نويسنده , , Lawrence S. Melvin Jr.، نويسنده , , Frank W. Rusek، نويسنده , , Jeanene E. Tickner، نويسنده , , John B. Cheng، نويسنده , , John T. Shirley، نويسنده ,
Abstract :
A series of pyridine chromanols were synthesized and evaluated as LTD4-antagonists (LTD4-A). The quinoline sidechain of this class of such agents, as exemplified by REV-5901, has until now been deemed as essential for potent activity. However, by manipulating substituents on a pyridine ring, quinoline-like potency can be achieved. The results indicate that this is a function of pKa.
