Author/Authors :
Philippe Gerardin، نويسنده , , Mohammed Ahrach، نويسنده , , Raphael Schneider، نويسنده , , Florence Houillon، نويسنده , , Bernard Loubinoux، نويسنده , , Mathieu Spreng، نويسنده , , Jean Luc Colin، نويسنده ,
Abstract :
Synthesis and biological testing of new 2-[4-(2-(2-amino-4-thiazolyl)-(Z)-2-(methoxyimino) acetylamino)-3-oxo-2-isoxazolidinyl]-2-aryloxy acetic acids analogs of lactivicin are described. The new products were obtained by addition of cycloserine derivatives on t-butyl 2-aryloxy-2-bromo acetate. Substitution on the aryloxy group modifies its leaving ability and allows different levels of activation of the γ-lactam ring.
