Structure-activity relationships of sulfur-containing triazole antifungals

Alkylthio and alkylsulfonyl derivatives of antifungal SM-8668 (3) were synthesized and estimated for their activities in vitro and in vivo. Derivatives having pentylthio, heptylthio or nonylthio group showed potent activities against both candidiasis and aspergillosis. The introduction of hydroxyl group at the end of their alkyl chain made their activities stronger.