Author/Authors :
Kan-ichi Konobu، نويسنده , , Misao Toyomoto، نويسنده , , Yoshihiko Murai، نويسنده , , Eriko Yamamoto، نويسنده , , Tetsutaro Kimachi، نويسنده , , Kiyoshi Bessho، نويسنده , , Fumio Yoneda، نويسنده ,
Abstract :
10-n-Butyl-3-methyl-5-deazaflavo-6,9-quinone (5-dFlQ) significantly stimulated the state 4 respiration in mitochondria in a concentration-dependent manner. The respiration inhibited by rotenone and antimycin A was recovered by the addition of 5-dFlQ. These facts suggest that 5-dFlQ acts as electron carriers such as flavins or ubiquinone in the mitochondrial respiratory chain and forms a new pathway for electron transfer.
