Title of article
The development of a novel series of non-peptide tachykinin NK3 receptor selective antagonists
Author/Authors
P. Boden، نويسنده , , J. M. Eden، نويسنده , , J. Hodgson، نويسنده , , D. C. Horwell، نويسنده , , M. C. Pritchard، نويسنده , , J. Raphy، نويسنده , , N. Suman-Chauhan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
1773
To page
1778
Abstract
In this paper we describe the transformation of a series of modified dipeptide NK3 receptor selective ligands, previously developed from a hit identified from the screening of a dipeptide chemical library, into non-peptide, nanomolar affinity NK3 receptor selective antagonists eg. PD160946 and PD161182. PD 161182 blocks senktide-induced human NK3 receptor mediated increases in intracellular calcium levels with a Ke of 0.88nM.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787598
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