Title of article
Protein kinase C inhibitory activities of balanol analogs bearing carboxylic acid replacements
Author/Authors
Julia M. Heerding، نويسنده , , John W. Lampe، نويسنده , , James W. Darges، نويسنده , , Mark L. Stamper، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
4
From page
1839
To page
1842
Abstract
A variety of balanol analogs bearing carboxylic acid replacements (amides, sulfonamides and tetrazoles) were synthesized and evaluated for protein kinase C (PKC) inhibitory activity. In general, those compounds which bear an acidic proton (pKa ≤ 7.6) display potent PKC activity, and show selectivity for PKC over other kinases. Prodrugs are excellent tools for increasing cellular activity of some acid replacements.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787610
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