in vivo potent antimalarial 1,2,4-trioxanes: Synthesis and activity of 8-(α-arylvinyl)-6,7,10-trioxaspiro[4,5]decanes and 3-(α-arylvinyl)-1,2,5-trioxaspiro[5,5]undecanes against Plasmodium berghei in mice

Fourteen new trioxanes belonging to 6,7,10-trioxaspiro[4,5]decane and 1,2,5-trioxaspiro[5,5]undecane series have been synthesized and screened against Plasmodium berghei in mice. Several of these trioxanes show promising blood schizontocidal activity.