Title of article
Novel PKC inhibitory analogs of balanol with replacement of the ester functionality
Author/Authors
G. Erik Jagdmann Jr.، نويسنده , , Jean M. Defauw، نويسنده , , Yen-Shi Lai، نويسنده , , Heidi M. Crane، نويسنده , , Steven E. Hall، نويسنده , , John A. Buben، نويسنده , , Hong Hu، نويسنده , , Paul A. Gosnell، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
2015
To page
2020
Abstract
Balanol ((−)-1) is a potent protein kinase inhibitory natural product isolated from the fungus Verticillium balanoides. The presence of an ester functionality in this molecule has prompted concern over the metabolic stability of balanol, and has led to a search for active analogs lacking this moiety. The synthesis and serum stability for some of these is presented herein.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787645
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