Author/Authors :
Yves Leblanc، نويسنده , , JacquesYves Gauthier، نويسنده , , Diane Ethier، نويسنده , , Jocelyne Guay، نويسنده , , Joseph Mancini، نويسنده , , Denis Riendeau، نويسنده , , Philip Tagari، نويسنده , , Philip Vickers، نويسنده , , Elizabeth Wong، نويسنده , , Petpiboon Prasit، نويسنده ,
Abstract :
A series of 2,3-diarylthiophene compounds was prepared and their biological activities were evaluated against human Cox-1 and Cox-2 enzymes. It appears that the methylsulfone group is essential for both the activity and selectivity for the Cox-2 enzyme. Removal of the methylsulfone group gave relatively selective Cox-1 inhibitors.
