Author/Authors :
Yen-Shi Lai*، نويسنده , , David S. Menaldino، نويسنده , , Jeffrey B. Nichols، نويسنده , , G. Erik Jagdmann Jr.، نويسنده , , Frankie Mylott، نويسنده , , Jan Gillespie، نويسنده , , Steven E. Hall، نويسنده ,
Abstract :
Analogs 3–5 of balanol (−)-1, a potent protein kinase C (PKC) inhibitor, were synthesized with the perhydroazepine moiety replaced by a smaller ring. Their in vitro inhibitory activities against PKC revealed a significant relationship between ring size and potency.
