Synthesis and PKC inhibitory activities of balanol analogs with a cyclopentane substructure

Compounds 4–7, analogs of the potent protein kinase C (PKC) inhibitor balanol (−)-1, were synthesized and their potency against PKC was compared with racemic balanol and other related analogs. These cyclopentane-based analogs were found to be, in general, more potent PKC inhibitors than balanol.