Author/Authors :
Yuehua He، نويسنده , , Serge Groleau، نويسنده , , RenéC. -Gaudreault، نويسنده , , Madeleine Caron، نويسنده , , Hélène-M. Thérien، نويسنده , , Gervais Bérubé، نويسنده ,
Abstract :
In our search for a chemotherapeutic agent with a better therapeutic index and selectivity for the treatment of breast cancer, we have synthesized cytotoxic triphenylethylene derivatives. The synthesis of this type of compound is straightforward and efficient. The biological activity of these compounds was evaluated in vitro on ER+ and ER- human breast tumor cell lines: MCF-7 and MDA-MB-231.
