Title of article
A series of conformationally and sterically constrained analogs of N-phenyl-N′-aralkylurea ACAT inhibitors
Author/Authors
Bharat K. Trivedi، نويسنده , , Ann Holmes، نويسنده , , Terri S. Purchase، نويسنده , , Arnold D. Essenburg، نويسنده , , Katherine L. Hamelehle، نويسنده , , Brian R. Krause، نويسنده , , MaryKay Shaw Hes، نويسنده , , Richard L. Stanfield، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
2229
To page
2234
Abstract
A series of conformationally and sterically constrained analogs of N-phenyl-N′-aralkylureas has been synthesized and evaluated as potential ACAT inhibitors. Most of these analogs are potent inhibitors of ACAT in vitro and lower plasma cholesterol in an acute in vivo model of hypercholesterolemia.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787686
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