A series of conformationally and sterically constrained analogs of N-phenyl-N′-aralkylurea ACAT inhibitors

A series of conformationally and sterically constrained analogs of N-phenyl-N′-aralkylureas has been synthesized and evaluated as potential ACAT inhibitors. Most of these analogs are potent inhibitors of ACAT in vitro and lower plasma cholesterol in an acute in vivo model of hypercholesterolemia.