Title of article :
Aliphatic replacements of the biphenyl moiety of the nonpeptidyl growth hormone secretagogues L-692,429 and L-692,585
Author/Authors :
Lin Chu، نويسنده , , Helmut Mrozik، نويسنده , , Michael H. Fisher، نويسنده , , Jeannette E. Brown، نويسنده , , Kang Cheng، نويسنده , , Wanda W. -S. Chan، نويسنده , , William R. Schoen، نويسنده , , Matthew J. Wyvratt Jr.، نويسنده , , Bridget S. Butler، نويسنده , , Roy G. Smith، نويسنده ,
Abstract :
Replacement of the central phenyl ring of the biphenyl moiety in the novel growth hormone (GH) secretagogues L-692,429 and L-692,585 with partially or completely saturated surrogates has been investigated. The cyclohexenyl analogue 37 displayed GH releasing activity comparable to L-692,585, indicating that the aromaticity of this central ring is not critical for bioactivity and that this ring may serve primarily to orient the benzolactam and phenyltetrazole pharmacophores.
