Pyrazolo[3,4-d]pyrimidines; adenosine receptor selectivity

Substitution of 1-phenylpyrazolo[3,4-d]pyrimidines at C6 (corresponding to C2 of xanthines/adenosines) with thioethers containing amide moieties has resulted in compounds with A1 and A2a adenosine receptor selectivity. This further demonstrates that distal moieties can modify receptor selectivity.