Title of article
The enantioselective synthesis and antiinflammatory activity of novel aryl-sphingolipid PKC inhibitors
Author/Authors
Gregory Merriman، نويسنده , , John J. Tegeler، نويسنده , , R. Richard L. Hamer، نويسنده , , Barbara S. Rauckman، نويسنده , , Brian S. Freed، نويسنده , , Ellen S. Kurtz، نويسنده , , Steven C. Bailey، نويسنده , , Marie Ortega-Nanos، نويسنده , , Penelope A. Przekop، نويسنده , , Luther Hellyer، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
2483
To page
2488
Abstract
Recently we identified three promising topically active antiinflammatory agents (2, 3, and 4) from a series of racemic aryl-sphingolipids that inhibit protein kinase C (PKC). We now wish to report the enantioselective synthesis of the aforementioned leads and their comparative biological profile. The individual enantiomers examined are equipotent to their racemate in vitro and in vivo.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787732
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