Title of article
High-affinity FKBP-12 ligands derived from (R)-(−)-carvone. Synthesis and evaluation of FK506 pyranose ring replacements
Author/Authors
John H. Tatlock، نويسنده , , Vincent J. Kalish، نويسنده , , H. E. Parge، نويسنده , , Daniel R. Knighton، نويسنده , , Richard E. Showalter، نويسنده , , Christina T. Lewis، نويسنده , , J. V. French، نويسنده , , J. Ernest Villafranca، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
2489
To page
2494
Abstract
The preparation and evaluation of potent small molecule inhibitors of FKBP-12 rotamase activity is described. These ligands contain many of the structural features of the FK506 pyranose ring region, yet are synthetically more accessible. The versatility of these FKBP-12 ligands is demonstrated with respect to effector domain exploration.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787733
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