Author/Authors :
Pierre Deprez، نويسنده , , Jacques Guillaume، نويسنده , , Alain Corbier، نويسنده , , Michel Fortin، نويسنده , , Jean-Paul Vevert، نويسنده , , Bertrand Heckmann، نويسنده ,
Abstract :
Introduction of an α-hydroxyacid moiety in position 5 of the imidazole ring within the imidazolyl biphenyl sulfonyl urea series significantly increased AT2 binding. Structure activity relationship around this moiety is described and gave rise to balanced AII inhibitors with nanomolar affinity on both AT1 and AT2 receptors and with an AT2/AT1 ratio of between 0.4 and 3.
