Title of article
Balanced AT1 and AT2 angiotensin II antagonists. II. Potent 5 α-hydroxyacid imidazolyl biphenyl sulfonylureas
Author/Authors
Pierre Deprez، نويسنده , , Jacques Guillaume، نويسنده , , Alain Corbier، نويسنده , , Michel Fortin، نويسنده , , Jean-Paul Vevert، نويسنده , , Bertrand Heckmann، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
2611
To page
2616
Abstract
Introduction of an α-hydroxyacid moiety in position 5 of the imidazole ring within the imidazolyl biphenyl sulfonyl urea series significantly increased AT2 binding. Structure activity relationship around this moiety is described and gave rise to balanced AII inhibitors with nanomolar affinity on both AT1 and AT2 receptors and with an AT2/AT1 ratio of between 0.4 and 3.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787754
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