Title of article :
6,3ʹ-Dinitroflavone, a novel high affinity ligand for the benzodiazepine receptor with potent anxiolytic properties
Author/Authors :
Mariel Marder، نويسنده , , Haydee Viola، نويسنده , , Cristina Wasowski، نويسنده , , Claudia Wolfman، نويسنده , , Peter G. Waterman، نويسنده , , Jorge H. Medina، نويسنده , , Alejandro C. Paladini، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1995
Abstract :
6,3ʹ-Dinitroflavone (2) and 6,4ʹ-dinitroflavone (3), prepared by direct nitration of flavone (1), were found to be ligands for the benzodiazepine receptor (BDZ-R). Compound 2, with a Ki= 12 nM, produced potent anxiolytic effects in mice at a dose of 1 μg/Kg.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
