Title of article
6,7,8,9-tetrahydro-3-hydroxy-1H-1-benzazepine-2,5-diones via a diels-alder reaction:antagonists with a non-planar hydrophobic region for NMDA receptor glycine sites
Author/Authors
Anthony P. Guzikowski، نويسنده , , Jon Hawkinson، نويسنده , , Eckard Weber، نويسنده , , John F. W. Keana، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
2
From page
2747
To page
2748
Abstract
Benzazepines 10a, 10b and 12 were prepared via a Diels-Alder reaction of dienes 5a and 5b with 6 followed by a Schmidt reaction on 9a, 9b and 11 then demethylation. The potencies of 10b and 12 for NMDA receptor glycine sites demonstrate binding site tolerance to antagonists with a non-planar hydrophobic region.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787779
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