Title of article
A bis-[N-3-(1-hydroxy-1-methyl-ethyl)-benzyl)-cyclic urea as a HIV protease inhibitor
Author/Authors
Wendell W. Wilkerson، نويسنده , , Andrea Y. Hollis، نويسنده , , Walter W. Cheatham، نويسنده , , Gilbert N. Lam، نويسنده , , Susan Erickson-Viitanen، نويسنده , , Lee Bacheler، نويسنده , , Beverly C. Cordova، نويسنده , , Ronald M. Klabe، نويسنده , , James L. Meek، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
3027
To page
3032
Abstract
Synthetic efforts to overcome the metabolic oxidative degradation of the HIV protease inhibitory cyclic urea DMP323, a benzyl alcohol, have led to the discovery of a tertiary carbinol with superior affinity for the viral protease and more potent inhibitory activity against viral replication. Synthetic approaches to this new carbinol and comparative analysis of its pharmacology and pharmacokinetics are presented.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787830
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