Title of article
Probing the P3′ pocket of stromelysin with piperazic acid analogs
Author/Authors
David A. Nugiel، نويسنده , , Kim Jacobs، نويسنده , , Carl P. Decicco، نويسنده , , David J. Nelson، نويسنده , , Robert A. Copeland، نويسنده , , Karl D. Hardman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
4
From page
3053
To page
3056
Abstract
The preparation and SAR of several piperazic acid-based stromelysin (MMP-3) inhibitors is presented. The standard P3′ methyl amide substituent can be replaced by other carboxy based substituents and maintain good binding affinity. Removal of a hydrogen-bond acceptor results in a 30-fold decrease in activity.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787835
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