Anti HIV-1 activity of a hydrophilic cyclosporin derivative with improved binding affinity to cyclophilin A

Due to its conformation, the hydrophilic compound [(D)MeSer-3, (4-OH)MeLeu-4] cyclosporin, 3, shows high affinity for cyclophilin A. This property, together with its lack of immunosuppression, confers 3 with very interesting anti HIV-1 activity.