Title of article :
Synthesis and NK-2 antagonist effect of 1,6-diphenyl-pyrazolo [3,4-d]-thiazolo[3,2-a]4H-pyrimidin-4-one
Author/Authors :
Salvatore Guccione، نويسنده , , Maria Modica، نويسنده , , Jeanette Longmore، نويسنده , , DAVID SHAW، نويسنده , , Gloria Uccello Barretta، نويسنده , , Andrea Santagati، نويسنده , , Maria Santagati، نويسنده , , Filippo Russo، نويسنده ,
Abstract :
1,6-Diphenyl-pyrazolo[3,4-d]thiazolo[3,2-a]4H-pyrimidin-4-one caused parallel displacement of the dose-response curve to the NK-2 receptor agonist in the guinea pig trachea suggesting it acts as a competitive antagonist. It is not active in the NK-1 and NK-3 receptor binding assays. A Ca++ channel blocking action at the voltage-operated channels (L-type) was observed.
