Author/Authors :
Bradley D. Tait، نويسنده , , Richard D. Dyer، نويسنده , , Bruce J. Auerbach، نويسنده , , Dirk Bornemeier، نويسنده , , Linda Guilds-Zamarka، نويسنده , , Maritza Oxender، نويسنده , , Bruce D. Roth، نويسنده , , Bharat K. Trivedi، نويسنده , , Joseph A. Cornicelli، نويسنده ,
Abstract :
A potent 15-lipoxygenase (15-LO) inhibitor, compound 6, was identified by mass screening the Parke-Davis compound portfolio. The active moiety of compound 6 was determined to be the catechol functionality. Additional analogs were prepared and analyzed for inhibitory activity against 5-, 12-, and 15- lipoxygenase.
