• Title of article

    Synthesis of highly potent RXR-specific retinoids: The use of a cyclopropyl group as a double bond isostere

  • Author/Authors

    Vidyasagar Vuligonda، نويسنده , , Yuan Lin، نويسنده , , Roshantha A. S. Chandraratna، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 1996
  • Pages
    6
  • From page
    213
  • To page
    218
  • Abstract
    Retinoids act through two distinct hormonal pathways activated by RAR and RXR ligands. We describe the synthesis of C9---C10 locked retinoid analogs, including the most potent RXR - specific agonist known to date (Compound 5), and discuss the structural features that lead to this specificity.
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    1996
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    787887

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=787887