Author/Authors :
Christophe Verbruggen، نويسنده , , Sofie De Craecker، نويسنده , , Padinchare Rajan، نويسنده , , Xian-Yun Jiao، نويسنده , , Marianne Borloo، نويسنده , , Keith Smith، نويسنده , , Alan H. Fairlamb، نويسنده , , Achiel Haemers، نويسنده ,
Abstract :
A series of phosphonic and phosphinic acid derivatives of glutathione were synthesized as potential inhibitors of glutathionylspermidine synthetase, an essential enzyme in the biosynthesis of trypanothione in trypanosomatids. The compounds showed moderate activity.
