Title of article :
L-162,389: a potent orally active angiotensin II receptor antagonist with balanced affinity to both AT1 and AT2 receptor subtypes
Author/Authors :
R. A. Rivero، نويسنده , , N. J. Kevin، نويسنده , , S. D. Kivlighn، نويسنده , , G. J. Zingaro، نويسنده , , R. S. Chang، نويسنده , , W. J. Greenlee، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1996
Abstract :
Simple modifications made to our potent angiotensin II AT1 selective clinical candidate MK-996 provided a compound with balanced binding affinity to both the AT1 and the AT2 receptor subtype. This compound, L-162,389, is orally active in rats and dogs.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
