Title of article
L-162,389: a potent orally active angiotensin II receptor antagonist with balanced affinity to both AT1 and AT2 receptor subtypes
Author/Authors
R. A. Rivero، نويسنده , , N. J. Kevin، نويسنده , , S. D. Kivlighn، نويسنده , , G. J. Zingaro، نويسنده , , R. S. Chang، نويسنده , , W. J. Greenlee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
307
To page
310
Abstract
Simple modifications made to our potent angiotensin II AT1 selective clinical candidate MK-996 provided a compound with balanced binding affinity to both the AT1 and the AT2 receptor subtype. This compound, L-162,389, is orally active in rats and dogs.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787906
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