The smooth muscle cell antiproliferative activity of heparan sulfate model oligosaccharides

Heparan sulfate model oligosaccharides were devised with the simplyfying assumptions that i) carboxyl-reduction and subsequent sulfation of heparan sulfate does not decrease the SMC antiproliferative activity, and ii) N-Sulfates in glucosamines can be replaced by O-sulfates. These heparan sulfate model oligosaccharides are more active than analogous heparin fractions.