Title of article
The prooligonucleotide approach. III: Synthesis and bioreversibility of a chimeric phosphorodithioate prooligonucleotide
Author/Authors
Guilem Tosquellas، نويسنده , , Isabelle Barber، نويسنده , , François Morvan، نويسنده , , Bernard Rayner، نويسنده , , Jean-Louis Imbach، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
457
To page
462
Abstract
Alkylation of a central gap of three phosphorodithioate linkages into a dodecathymidine methylphosphonate with methylacylthioethyl iodide (Me-SATE-I) yielded the corresponding neutral oligonucleotide. Upon incubation of the resulting non ionic prooligonucleotide in cell extracts, the bioreversible Me-SATE masking groups were selectively removed by carboxyesterases present in the milieu.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787937
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