Title of article
J-104,123, a novel and orally-active inhibitor of squalene synthase: Stereoselective synthesis and cholesterol lowering effects in dogs
Author/Authors
Yoshikazu Iwasawa، نويسنده , , Jun Shibata، نويسنده , , Morihiro Mitsuya، نويسنده , , Hitoshi Masaki، نويسنده , , Masahiro Hayashi، نويسنده , , Tetsuya Kanno، نويسنده , , Yoshio Sawasaki، نويسنده , , Akihiro Hisaka، نويسنده , , Toshio Kamei، نويسنده , , Koji Tomimoto، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
463
To page
466
Abstract
J-104,123, a potent inhibitor of squalene synthase having monocarboxylic acid structure, was discovered by chemical modification of J-104,118. An oral dose of J-104,123 lowered serum cholesterol levels in dogs. J-104,123 was synthesized stereoselectively from methyl (R)-3-hydroxybutyrate.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787938
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