Synthesis of analogues of monic acids A and C: Potential herbicides and inhibitors of isoleucyl tRNA synthetase

The m-substituted benzene compounds 16–21 and biphenyl derivatives 25–27 have been synthesised as simplified analogues of monic acids A 3 and C 4. In addition the disubstituted 1,3-dioxanes 41–43 have been prepared and all compounds tested as herbicides and for their ability to inhibit spinach chloroplast isoleucyl tRNA synthetase.