Title of article
The identification of cyclooxygenase-1 inhibitors from 4-thiazolidinone combinatorial libraries
Author/Authors
Gary C. Look، نويسنده , , John R. Schullek، نويسنده , , Christopher P. Holmes، نويسنده , , Jason P. Chinn، نويسنده , , Eric M. Gordon، نويسنده , , Mark A. Gallop، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
707
To page
712
Abstract
Three 4-thiazolidinone libraries, each containing up to 540 compounds, were prepared and assayed for inhibition of the enzyme cyclooxygenase-1 (COX-1). Deconvolution analysis led to the identification of a compound that is equipotent with the commercial COX-1 inhibitors ibuprofen and phenylbutazone
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787985
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