Author/Authors :
Harriet W. Hamilton، نويسنده , , Bradley D. Tait، نويسنده , , Christopher Gajda، نويسنده , , Susan E. Hagen، نويسنده , , Donna Ferguson، نويسنده , , Elizabeth A. Lunney، نويسنده , , Alexander Pavlovsky، نويسنده , , Peter J. Tummino، نويسنده ,
Abstract :
Publications from our laboratories have recently described a series of 3-thioaryl substituted-4-hydroxy-pyrones1 as HIV protease inhibitors. The current work examines the analogous 5,6-dihydro-2H-pyran-2-ones with 6,6-substitutions focusing on the use of 1°, 2°, and 3° alkyl amides of various chain lengths to fill the S1 through S3 enzyme pockets.
