Author/Authors :
Timothy A. Grese، نويسنده , , James P. Sluka، نويسنده , , Henry U. Bryant، نويسنده , , Harlan W. Cole، نويسنده , , John R. Kim، نويسنده , , David E. Magee، نويسنده , , Ellen R. Rowley، نويسنده , , Masahiko Sato، نويسنده ,
Abstract :
Several 2,3-diarylbenzopyrans have been evaluated in an ovariectomized rat model and found to exhibit tissue selective estrogen agonist activity on bone and serum lipid parameters. A structural model that accounts for the pharmacological similarity of these benzopyrans and the benzothiophene SERM, raloxifene, is proposed.
