Title of article
Synthesis and anti-HIV activity of dibenzylbutyrolactone lignans
Author/Authors
Liming Yang، نويسنده , , Shwu-Jiuan Lin، نويسنده , , Tsang-Hsiung Yang، نويسنده , , Kuo-Hsiung Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
941
To page
944
Abstract
Five optically active dibenzylbutyrolactone lignans were synthesized through a lipase-catalyzed transesterification route, and evaluated for their inhibitory activity against HIV-1 replication in acutely infected H9 cells. Compounds 1 and 2 demonstrated anti-HIV replication activity with an EC50 values of 2.2 and 0.16 μg/ml and a therapeutic index values of 9.1 and 5, respectively. Structure-antiviral activity relationships are discussed.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788035
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