Title of article
Synthesis and antibacterial activity of new tropone-substituted phenyloxazolidinone antibacterial agents 1. Identification of leads and importance of the tropone substitution pattern
Author/Authors
Michael R. Barbachyn، نويسنده , , Dana S. Toops، نويسنده , , Debra A. Ulanowicz، نويسنده , , Kevin C. Grega، نويسنده , , Steven J. Brickner، نويسنده , , Charles W. Ford، نويسنده , , Gary E. Zurenko، نويسنده , , Judith C. Hamel، نويسنده , , Ronda D. Schaadt، نويسنده , , Douglas Stapert، نويسنده , , Betty H. Yagi، نويسنده , , Jerry M. Buysse، نويسنده , , William F. Demyan، نويسنده , , James O. Kilburn، نويسنده , , Suzanne E. Glickman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
1003
To page
1008
Abstract
Incorporation of a substituted tropone moiety into the para position of suitably functionalized 3-phenyl-2-oxazolidinones affords novel and potent antibacterial agents. The effect of the tropone regioisomer and its attendant substituents on antibacterial activity is discussed. Analogues such as 11c and 13b display in vitro and in vivo activity approaching that of the current clinical benchmark, vancomycin.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788048
Link To Document