Author/Authors :
Timothy M. Willson and Shawn P. Williams، نويسنده , , Brad R. Henke، نويسنده , , Tanya M. Momtahen، نويسنده , , Deanna T. Garrison، نويسنده , , Linda B. Moore، نويسنده , , Nora G. Geddie، نويسنده , , Philip G. Baer، نويسنده ,
Abstract :
The utility of the bone targeting 4-carboxy-3-hydroxy-1,2-pyrazole heterocycle was tested by the synthesis of hybrids with the non-steroidal estrogen hexestrol. Compounds 1 and 2 demonstrated significant hydroxyapatite affinity, while maintaining weak estrogenic activity in whole cell assays.
