Title of article
1,3-diaryl-2-carboxyindoles as potent non-peptide endothelin antagonists
Author/Authors
Amy M. Bunker، نويسنده , , Jeremy J. Edmunds، نويسنده , , Kent A. Berryman، نويسنده , , Donnelle M. Walker، نويسنده , , Michael A. Flynn، نويسنده , , Kathy M. Welch، نويسنده , , Annette M. Doherty، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
1061
To page
1066
Abstract
Endothelin-1 is a potent vasoconstrictor that is thought to be involved in many human disease states. We have developed a series of indole non-peptide endothelin antagonists including PD 159110 (31), an ETA selective antagonist, and PD 159020 (37), a non-selective ETA/ETB antagonist. The discovery, synthesis, and structure-activity relationships of this series of compounds are described.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788060
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