Author/Authors :
Bruce A. Steinbaugh، نويسنده , , Harriet W. Hamilton، نويسنده , , J. V. N. Vara Prasad، نويسنده , , Kimberly S. Para، نويسنده , , Tummino Peter J.، نويسنده , , Donna Ferguson، نويسنده , , Elizabeth A. Lunney، نويسنده , , C. John Blankley، نويسنده ,
Abstract :
In a study of 4-hydroxy-pyran-2-ones as possible inhibitors of HIV protease, a series of compounds were synthesized following the Topliss operational scheme for substitution on a phenyl group at the 6 position of the pyrone. In addition, a number of compounds with polar substituents were made.
