Title of article
Synthesis and antitumor activity of novel duocarmycin derivatives
Author/Authors
Akira Asai، نويسنده , , Satoru Nagamura، نويسنده , , Eiji Kobayashi، نويسنده , , Katushige Gomi، نويسنده , , Hiromitsu Saito، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
1215
To page
1220
Abstract
A series of Duocarmycin B2 analogs bearing simplified right hand segments (Seg-Bs) with the protected phenolic hydroxyl group in left hand segment (Seg-A) was synthesized. Among them, the cinnamoyl derivatives 6c and 6d exhibited potent antitumor activity against in vivo murine tumor models in the wider range of doses without detectable toxic effects than DUMB2.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788090
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