Title of article
N-(substituted-phenyl) piperazines: antagonists with high binding and functional selectivity for dopamine D4 receptors
Author/Authors
Izzy Boyfield، نويسنده , , Martyn C. Coldwell، نويسنده , , Michael S. Hadley، نويسنده , , Maureen A. M. Healy، نويسنده , , Amanda Johns، نويسنده , , David J. Nash، نويسنده , , Graham J. Riley، نويسنده , , Emma E. Scott، نويسنده , , Stephen A. Smith، نويسنده , , Geoffrey Stemp، نويسنده , , Karl Wilson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
1227
To page
1232
Abstract
A series of N-(substituted-phenyl) piperazine derivatives was prepared as selective antagonists of the dopamine D4 receptor. Many analogues possessed a binding selectivity of over 100 fold for D4 over D2 receptors. In functional studies in the microphysiometer, compound 24 showed a selectivity over dopamine D2 receptors of greater than 1000 fold.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788092
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