Title of article
Highly potent and selective inhibitors of endothelin converting enzyme
Author/Authors
Samuel Chackalamannil، نويسنده , , Chia-Shin Chung، نويسنده , , Andrew W. Stamford، نويسنده , , Brian A. McKittrick، نويسنده , , Yuguang Wang، نويسنده , , Hsingan Tsai، نويسنده , , Reneé Cleven، نويسنده , , Ahmad Fawzi، نويسنده , , Michael Czarniecki، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
1257
To page
1260
Abstract
Phosphinic acid derivatives, represented by structure 1, have been synthesized and evaluated as endothelin converting enzyme (ECE) inhibitors. Several of these compounds (for example, 1b, 1c, and 1f) were found to be potent inhibitors of ECE with a high degree of selectivity against neutral endopeptidase (NEP).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
788098
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