Author/Authors :
Mark P. Wentland، نويسنده , , Robert B. Perni، نويسنده , , Jianhua I. Huang، نويسنده , , Ronald G. Powles، نويسنده , , Suzanne C. Aldous، نويسنده , , Kristina M. Klingbeil، نويسنده , , A. Danielle Peverly، نويسنده , , Ronald G. Robinson، نويسنده , , Thomas H. Corbett، نويسنده , , Julie L. Jones، نويسنده , , James B. Rake، نويسنده , , Susan A. Coughlin، نويسنده ,
Abstract :
Novel derivatives of SR 233377 (1, WIN 33377) where a pyrazolo ring fusion has been incorporated at the 1- and 9-positions of the thioxanthone ring displayed outstanding in vivo efficacy against the murine solid tumor Panc 03 (T/C values of 0% with log cell kill 2.0). No relationship between structure and Panc 03 activity was observed because all analogues studied were highly active.
